Neuroinflammation in schizophrenia: the role of nuclear factor kappa B
Neuroinflammation, particularly in the dorsolateral prefrontal cortex, is well-established in a
subset of people with schizophrenia, with significant increases in inflammatory markers …
subset of people with schizophrenia, with significant increases in inflammatory markers …
What genes are differentially expressed in individuals with schizophrenia? A systematic review
AK Merikangas, M Shelly, A Knighton, N Kotler… - Molecular …, 2022 - nature.com
Schizophrenia is a severe, complex mental disorder characterized by a combination of
positive symptoms, negative symptoms, and impaired cognitive function. Schizophrenia is …
positive symptoms, negative symptoms, and impaired cognitive function. Schizophrenia is …
Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex
We used the 10x Genomics Visium platform to define the spatial topography of gene
expression in the six-layered human dorsolateral prefrontal cortex. We identified extensive …
expression in the six-layered human dorsolateral prefrontal cortex. We identified extensive …
Single-nucleus transcriptome analysis reveals cell-type-specific molecular signatures across reward circuitry in the human brain
MN Tran, KR Maynard, A Spangler, LA Huuki… - Neuron, 2021 - cell.com
Single-cell gene expression technologies are powerful tools to study cell types in the human
brain, but efforts have largely focused on cortical brain regions. We therefore created a …
brain, but efforts have largely focused on cortical brain regions. We therefore created a …
Analysis of the caudate nucleus transcriptome in individuals with schizophrenia highlights effects of antipsychotics and new risk genes
Most studies of gene expression in the brains of individuals with schizophrenia have
focused on cortical regions, but subcortical nuclei such as the striatum are prominently …
focused on cortical regions, but subcortical nuclei such as the striatum are prominently …
Developmental excitation-inhibition imbalance underlying psychoses revealed by single-cell analyses of discordant twins-derived cerebral organoids
T Sawada, TE Chater, Y Sasagawa, M Yoshimura… - Molecular …, 2020 - nature.com
Despite extensive genetic and neuroimaging studies, detailed cellular mechanisms
underlying schizophrenia and bipolar disorder remain poorly understood. Recent progress …
underlying schizophrenia and bipolar disorder remain poorly understood. Recent progress …
Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability
We analyzed 131 human brains (44 neurotypical, 19 with Tourette syndrome, 9 with
schizophrenia, and 59 with autism) for somatic mutations after whole genome sequencing to …
schizophrenia, and 59 with autism) for somatic mutations after whole genome sequencing to …
Amygdala and anterior cingulate transcriptomes from individuals with bipolar disorder reveal downregulated neuroimmune and synaptic pathways
Recent genetic studies have identified variants associated with bipolar disorder (BD), but it
remains unclear how brain gene expression is altered in BD and how genetic risk for BD …
remains unclear how brain gene expression is altered in BD and how genetic risk for BD …
Isoform-level transcriptome-wide association uncovers genetic risk mechanisms for neuropsychiatric disorders in the human brain
Methods integrating genetics with transcriptomic reference panels prioritize risk genes and
mechanisms at only a fraction of trait-associated genetic loci, due in part to an overreliance …
mechanisms at only a fraction of trait-associated genetic loci, due in part to an overreliance …
Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits
Cigarette smoking is the leading cause of preventable morbidity and mortality. Genetic
variation contributes to initiation, regular smoking, nicotine dependence, and cessation. We …
variation contributes to initiation, regular smoking, nicotine dependence, and cessation. We …