Current management of aortic aneurysms relies exclusively on prophylactic operative repair
of larger aneurysms. Great potential exists for successful medical therapy that halts or …

Abdominal aortic aneurysm (AAA) is a severe vascular disease and a major public health
issue with an unmet medical need for therapy. This disease is featured by a progressive …

Objective—We previously established that neutrophil-derived dipeptidyl peptidase I (DPPI)
is essential for experimental abdominal aortic aneurysm (AAA) development. Because DPPI …

Background While numerous interventions effectively interfered with abdominal aortic
aneurysm (AAA) formation/progression in preclinical models, none of the successes …

Background Management of abdominal aortic aneurysms (AAAs) relies on surgical repair of
larger AAAs. Consequently medical interventions inhibiting AAA progression could greatly …

Abdominal aortic aneurysm (AAA) is a common disease associated with significant
cardiovascular morbidity and mortality. Up to now, there is still controversy on the choice of …

Objective—Perivascular adipose tissue (PVAT) is thought to play a role in vascular
homeostasis and in the pathogenesis of large vessel diseases, including abdominal aortic …

Background Human mesenchymal cells are culprit factors in vascular (patho) physiology
and are hallmarked by phenotypic and functional heterogeneity. At present, they are …

Objective The processes driving human abdominal aortic aneurysm (AAA) progression are
not fully understood. Although antiinflammatory and proteolytic strategies effectively quench …

Objective/Background Abdominal aortic aneurysm (AAA) is an individual and
socioeconomic burden in today's ageing society. Treatment relies on surgical exclusion of …