Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

DNA methylation is one of the most important epigenetic mechanisms to regulate gene
expression, which is highly dynamic during development and specifically maintained in …

Manipulations to slow biological aging and extend healthspan are of interest given the
societal and healthcare costs of our aging population. Herein we report on a randomized …

Ageing is characterized by the functional decline of tissues and organs and the increased
risk of ageing-associated disorders. Several 'rejuvenating'interventions have been proposed …

In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …

Over the past 20 years, breakthrough discoveries of chromatin-modifying enzymes and
associated mechanisms that alter chromatin in response to physiological or pathological …

Bisulfite sequencing has been the gold standard for mapping DNA modifications including 5-
methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) for decades,,–. However, this …

Background Nanopore long-read sequencing technology greatly expands the capacity of
long-range, single-molecule DNA-modification detection. A growing number of analytical …

Background Friend leukemia virus integration 1 (FLI1), an ETS transcription factor family
member, acts as an oncogenic driver in hematological malignancies and promotes tumor …