Despite increasing advances in the diagnosis and treatment for pancreatic cancer, the
mortality rate remains high world-wide. There is an urgent need for new therapies to improve …

Epigenetic modifications of gene expression comprise modifications of DNA by DNA
methylation and modifications of the histone proteins by acetylation, methylation …

Although the outcome of therapy for leukemia has improved over the years, mainly in
younger patients, less than a third of adults with acute myeloid leukemia (AMLa), for …

Among the most readily available chemical warfare agents, sulfur mustard (SM), also known
as mustard gas, has been the most widely used chemical weapon. SM causes debilitating …

Pancreatic carcinoma is currently considered as a rapidly progressive and fatal disease, and
is typically diagnosed late in its natural course. It is characterized by a poor diagnosis and …

Growing evidences show that epigenetic mechanisms play crucial roles in the genesis and
progression of many physiopathological processes. As a result, research in epigenetic grew …

Chronically-elevated blood glucose initiates a harmful series of processes in which toxic
reactive species play crucial roles. Oxidative as well as nitro-oxidative stress is harmful for …

We demonstrate for the first time the integration of a dumbbell probe with dual signal
amplification for the simultaneous detection of multiple DNA methyltransferases (MTases) …

During the past few decades, it has become increasingly apparent that heredity is not the
sole determining factor in disease development, such as cancer. This landmark work covers …

Lung and esophageal cancers and malignant pleural mesotheliomas are highly lethal
neoplasms that are leading causes of cancer-related deaths worldwide. Presently, limited …