We here report a simple assay system for DNA methyltransferase (DNMT) inhibitors based
on the HBx-induced DNA methylation of E-cadherin. A stable cell line named G1 was …

To date, Cancer remains a global threat due to its impact on growing life expectancy. With
the many efforts and methods of combating the disease, complete success remains a …

Tumorigenesis is traditionally thought to be caused by the imbalance between oncogenes
and tumor-suppressor genes. Epigenetics is a recently described phenomenon that uses an …

Una marca distintiva del cáncer humano desde la epigenética es el silenciamiento de los
genes supresores de tumores, junto con la hipermetilación del ADN. En esta revisión se …

The term epigenetic landscape was coined by CH Waddington to describe how cell fates
were established in development, visualized as valleys and ridges directing the …

Prostate cancer (PCa) is strongly influenced by epigenetic changes, which alter gene
expression and promote cancer growth. The most commonly altered epigenetic …

Background: 5-methylcytosine (m5c) is a common chemical alteration in DNA and RNA,
however unlike DNA modifying enzymes, the methyl-transferases that make m5c changes in …

Metylacja cytozyny do 5-metylocytozyny jest poreplikacyjną modyikacją DNA, odgrywającą
istotną rolę w transkrypcyjnym wyciszaniu genów. Proces ten polega na kowalencyjnym …