Context Male infertility is defined as the inability to conceive following 1 year of regular
unprotected intercourse. It is the causative factor in 50% of couples and a leading indication …

The functions of Sertoli cells in spermatogenesis have attracted much more attention
recently. Normal spermatogenesis depends on Sertoli cells, mainly due to their influence on …

The role of growth hormone (GH) in human fertility is widely debated with some studies
demonstrating improvements in oocyte yield, enhanced embryo quality, and in some cases …

Background Testicular architecture and sperm production are supported by a complex
network of communication between various cell types. These signals ensure fertility by …

Molecular mechanisms associated with human germ cell aplasia in infertile men remain
undefined. Here we perform single-cell transcriptome profiling to highlight differentially …

Persistent research over the past few decades has clearly established that the insulin-like
family of growth factors, which is composed of insulin and insulin-like growth factors 1 (IGF1) …

Sustaining and maintaining the intricate process of spermatogenesis is liable upon
hormones and growth factors acting through endocrine and paracrine pathways. The Sertoli …

It is clear that insulin-like growth factor-1 (IGF1) is important in supporting growth and
regulating metabolism. The IGF1 found in the circulation is primarily produced by the liver …

The steroidogenic cells in the testicle, Leydig cells, located in the interstitial compartment,
play a vital role in male reproductive tract development, maintenance of proper …

Context The phenotype and response to GH treatment of children with an IGF1R defect is
insufficiently known. Objective To develop a clinical score for selecting children with short …