A comprehensive review of genetic and epigenetic mechanisms that regulate BDNF expression and function with relevance to major depressive disorder
Major depressive disorder (MDD) is a mood disorder that affects behavior and impairs
cognition. A gene potentially important to this disorder is the brain derived neurotrophic …
cognition. A gene potentially important to this disorder is the brain derived neurotrophic …
The DNA methylation landscape of advanced prostate cancer
Although DNA methylation is a key regulator of gene expression, the comprehensive
methylation landscape of metastatic cancer has never been defined. Through whole …
methylation landscape of metastatic cancer has never been defined. Through whole …
What did we learn from the molecular biology of adrenal cortical neoplasia? From histopathology to translational genomics
Approximately one-tenth of the general population exhibit adrenal cortical nodules, and the
incidence has increased. Afflicted patients display a multifaceted symptomatology …
incidence has increased. Afflicted patients display a multifaceted symptomatology …
Integrated genomic characterization of adrenocortical carcinoma
G Assié, E Letouzé, M Fassnacht, A Jouinot… - Nature …, 2014 - nature.com
Adrenocortical carcinomas (ACCs) are aggressive cancers originating in the cortex of the
adrenal gland. Despite overall poor prognosis, ACC outcome is heterogeneous,. We …
adrenal gland. Despite overall poor prognosis, ACC outcome is heterogeneous,. We …
Predicting genome-wide DNA methylation using methylation marks, genomic position, and DNA regulatory elements
Background Recent assays for individual-specific genome-wide DNA methylation profiles
have enabled epigenome-wide association studies to identify specific CpG sites associated …
have enabled epigenome-wide association studies to identify specific CpG sites associated …
Telotristat etiprate, a novel serotonin synthesis inhibitor, in patients with carcinoid syndrome and diarrhea not adequately controlled by octreotide
MH Kulke, T O'Dorisio, A Phan… - Endocrine-Related …, 2014 - erc.bioscientifica.com
In this study, we i) assessed the metabolic profile of the normal adrenal cortex and medulla
of adult human subjects by means of 1 H-high-resolution magic-angle spinning nuclear …
of adult human subjects by means of 1 H-high-resolution magic-angle spinning nuclear …
Identification of a CpG island methylator phenotype in adrenocortical carcinomas
O Barreau, G Assie, H Wilmot-Roussel… - The Journal of …, 2013 - academic.oup.com
Purpose: DNA methylation is a mechanism for gene expression silencing in cancer. Limited
information is available for adrenocortical tumors. Abnormal methylation at the IGF2/H19 …
information is available for adrenocortical tumors. Abnormal methylation at the IGF2/H19 …
Distinct chromatin signatures of DNA hypomethylation in aging and cancer
Cancer is an aging‐associated disease, but the underlying molecular links between these
processes are still largely unknown. Gene promoters that become hypermethylated in aging …
processes are still largely unknown. Gene promoters that become hypermethylated in aging …
Antineoplastic effects of 1, 25 (OH) 2D3 and its analogs in breast, prostate and colorectal cancer
C Leyssens, L Verlinden… - Endocrine-related …, 2013 - erc.bioscientifica.com
Breast cancer is the most prevalent type of cancer in women and responsible for significant
female cancer-related mortality worldwide. In the Western world, over 80% of breast cancers …
female cancer-related mortality worldwide. In the Western world, over 80% of breast cancers …
Epigenetic regulation of placental gene expression in transcriptional subtypes of preeclampsia
Background Preeclampsia (PE) is a heterogeneous, hypertensive disorder of pregnancy,
with no robust biomarkers or effective treatments. We hypothesized that this heterogeneity is …
with no robust biomarkers or effective treatments. We hypothesized that this heterogeneity is …