T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

Abstract Immune-checkpoint inhibitors (ICBs), in addition to targeting CTLA-4, PD-1, and PD-
L1, novel targeting LAG-3 drugs have also been approved in clinical application. With the …

T cell exhaustion limits antitumor immunity, but the molecular determinants of this process
remain poorly understood. Using a chronic stimulation assay, we performed genome-wide …

Chronic antigen exposure during viral infection or cancer promotes an exhausted T cell
(Tex) state with reduced effector function. However, whether all antigen-specific T cell clones …

T cell exhaustion is a state of T cell dysfunction associated with expression of programmed
death 1 (PD-1). Exhausted CD8+ T cells are maintained by self-renewing stem-like T cells …

Reinvigorating the function of exhausted CD8+ T cells during chronic viral infection and
cancer is a major goal of current immunotherapy regimens. Here, we discuss recent …

In recent years, the tumour microenvironment (TME) of solid tumours has attracted more and
more attention from researchers, especially those non-tumour components such as immune …

Chimeric antigen receptor T (CAR-T) cell therapy has significantly improved the life
expectancy for patients with refractory or relapse B cell lymphoma. As for B cell acute …

Disulfidptosis is a newly discovered form of cell death. Not yet clearly classified as
programmed cell death or accidental cell death. This study aimed to create a novel …

The immune checkpoint blockade (ICB) response in human cancers is closely linked to the
gut microbiota. Here, we report that the abundance of commensal Lactobacillus johnsonii is …