MicroRNA-34a: the bad guy in age-related vascular diseases

A Raucci, F Macrì, S Castiglione, I Badi… - Cellular and Molecular …, 2021 - Springer
The age-related vasculature alteration is the prominent risk factor for vascular diseases
(VD), namely, atherosclerosis, abdominal aortic aneurysm, vascular calcification (VC) and …

Interleukin 6 in diabetes, chronic kidney disease, and cardiovascular disease: mechanisms and therapeutic perspectives

FF Kreiner, JM Kraaijenhof, M von Herrath… - Expert Review of …, 2022 - Taylor & Francis
Introduction Diabetes, chronic kidney disease (CKD) and cardiovascular disease (CVD) are
cardiometabolic diseases that remain amongst the leading causes of morbidity and …

Inflammasomes in the pathophysiology of aortic disease

M Wortmann, AS Peters, P Erhart, D Körfer, D Böckler… - Cells, 2021 - mdpi.com
Aortic diseases comprise aneurysms, dissections, and several other pathologies. In general,
aging is associated with a slow but progressive dilation of the aorta, along with increased …

Multifunctional role of nanoparticles for the diagnosis and therapeutics of cardiovascular diseases

I Arshad, A Kanwal, I Zafar, A Unar, M Hanane… - Environmental …, 2023 - Elsevier
The increasing burden of cardiovascular disease (CVD) remains responsible for morbidity
and mortality worldwide; their effective diagnostic or treatment methods are of great interest …

Genetic insights into therapeutic targets for aortic aneurysms: A Mendelian randomization study

Y Chen, X Xu, L Wang, K Li, Y Sun, L Xiao, J Dai… - …, 2022 - thelancet.com
Summary Background As aortic aneurysms (AAs) enlarge, they can become life-threatening
if left undiagnosed or neglected. At present, there is a lack of radical treatments for …

Early Progression of Abdominal Aortic Aneurysm is Decelerated by Improved Endothelial Barrier Function via ALDH2‐LIN28B‐ELK3 Signaling

K Yang, S Cui, J Wang, T Xu, H Du, H Yue… - Advanced …, 2023 - Wiley Online Library
The involvement of endothelial barrier function in abdominal aortic aneurysm (AAA) and its
upstream regulators remains unknown. Single‐cell RNA sequencing shows that disrupted …

Progress of Research into the Interleukin-1 Family in Cardiovascular Disease

Z Wu, C Luo, B Zheng - Journal of Inflammation Research, 2022 - Taylor & Francis
Inflammatory factors, such as the IL-1 family, are generally acknowledged to be involved in
systemic diseases and IL-1α and IL-1β, in particular, have been linked to cardiovascular …

The SNP rs4591246 in pri-miR-1-3p is associated with abdominal aortic aneurysm risk by regulating cell phenotypic transformation via the miR-1-3p/TLR4 axis

T Li, J Jing, L Sun, Y Gong, J Yang, C Ma… - International …, 2023 - Elsevier
Emerging evidence reveals that single nucleotide polymorphism (SNP) within miRNAs can
affect the risk of cardiovascular diseases. However, the role of miRNA SNPs in abdominal …

[HTML][HTML] Platelet protects angiotensin II-driven abdominal aortic aneurysm formation through inhibition of inflammation

X Liu, X Chen, C Xu, J Lou, Y Weng, L Tang - Experimental gerontology, 2022 - Elsevier
Background Inflammation is the primary cause of abdominal aortic aneurysm (AAA)
formation and development. It has been reported that platelets protect against septic shock …

[HTML][HTML] Aberrant mitochondrial dynamics: an emerging pathogenic driver of abdominal aortic aneurysm

M Ouyang, M Wang, B Yu - Cardiovascular Therapeutics, 2021 - hindawi.com
Abdominal aortic aneurysm (AAA) is defined as a progressive segmental dilation of the
abdominal aorta and is associated with high mortality. The characterized features of AAA …