It is now well accepted that many tumors undergo a process of clonal selection which means
that tumor antigens arising at various stages of tumor progression are likely to be …

Simple Summary The breakthrough of immunotherapy in melanoma has generated a
glimmer of hope for lethal triple negative breast cancer (TNBC). This review summarizes the …

Pathologies associated with uteroplacental hypoxia, such as preeclampsia are among the
leading causes of maternal and perinatal morbidity in the world. Its fundamental …

The placenta is a fast-evolving organ with large morphological and histological differences
across eutherians, but the genetic changes driving placental evolution have not been fully …

Polo-like kinases (Plks) are critical regulatory molecules during the cell cycle process. This
family has five members: Plk1, 2, 3, 4, and 5. Plk4 has been identified as a master regulator …

Analogies between placentation, in particular the behavior of trophoblast cells, and cancer
have been noted since the beginning of the twentieth century. To what degree these can be …

Placenta in certain species including the human has evolved as a highly invasive tumor-like
organ invading the uterus aned its vasculature to derive oxygen and nutrients for the fetus …

Polyploid giant cancer cells (PGCC) constitute a dangerous subpopulation of cancer cells
and are a driving force in cancer recurrence. These unique cells arise from diploid tumor …

During pregnancy, the mother's immune system has to tolerate the persistence of paternal
alloantigens without affecting the anti-infectious immune response. Consequently, several …

Results of immunotherapy in childhood solid cancer have been so far, with the exception of
neuroblastoma, quite disappointing. Lack of knowledge of the immune contexture of these …