Several distinct pathological patterns of glomerular inflammation are associated with
abnormal regulation of the complement system, specifically, with dysregulation of the …

In the past, most cases of bacterial infection–related glomerulonephritis (IRGN) occurred in
children following streptococcal upper respiratory tract or skin infections and were called …

The implementation of next‐generation sequencing technologies has provided a sharp
picture of the genetic variability in the components and regulators of the alternative pathway …

Two common variants in the gene encoding complement factor H (CFH), the Y402H
substitution (rs1061170, c. 1204C> T),,, and the intronic rs1410996 SNP,, explain 17% of …

Background Complement is a key component of the innate immune system, and variation in
genes that regulate its activation is associated with renal and other disease. We aimed to …

C3 glomerulonephritis is a clinicopathologic entity defined by the presence of isolated or
dominant deposits of C3 on immunofluorescence. To explore the effect of …

Genetically modified immune responses to infections and self-antigens initiate most forms of
GN by generating pathogen-and danger-associated molecular patterns that stimulate Toll …

A kidney biopsy is done to determine the etiology of the glomerulonephritis (GN) and the
severity of the lesion, to identify whether other lesions, related to or not related to the GN, are …

Results Among 21,374 patients (mean age= 48.3±18.3 years old; 50.8% men; 56.8% white;
38.3% black; 2.8% Latino; 1.4% Asian; 0.8% other), the frequency of diabetic …

Membranoproliferative glomerulonephritis (MPGN) is a pattern of injury that results from
subendothelial and mesangial deposition of Igs caused by persistent antigenemia and/or …