The prevalence, pathogenesis, predictors, and natural course of patients with recurrent
glomerulonephritis (GN) occurring after kidney transplantation remains incompletely …

Eculizumab might benefit C3 glomerulopathies mediated by dysregulation of the alternative
complement pathway. Here, we report renal biopsy findings before and after eculizumab …

Membranoproliferative glomerulonephritis is an uncommon kidney disorder characterized
by mesangial cell proliferation and structural changes in glomerular capillary walls. It can be …

The complement cascade comprises soluble and cell surface proteins and is an important
arm of the innate immune system. Once activated, the complement system rapidly generates …

Hemolytic uremic syndrome (HUS) is a rare, life-threatening disease characterized by
thrombocytopenia, microangiopathic hemolytic anemia, and acute renal failure. The atypical …

Complement defects are associated with an enhanced risk of a broad spectrum of infectious
as well as systemic or local inflammatory and thrombotic disorders. Inherited complement …

Factor I (FI) is a crucial inhibitor controlling all complement pathways due to its ability to
degrade activated complement proteins C3b and C4b in the presence of cofactors such as …

Autoantibodies targeting factor H (FH), which is a main alternative complement pathway
regulatory protein, have been well characterized in atypical hemolytic uremic syndrome …

Mutations in one or more genes encoding complement-regulatory proteins predispose to
atypical hemolytic uremic syndrome (aHUS) and its recurrence following kidney …

Proliferative GN is classified as immune complex-mediated or complement-mediated (C3
glomerulopathy). Immune complex-mediated GN results from glomerular deposition of …