The inflammatory kidney disease membranoproliferative glomerulonephritis type II (MPGN2)
is associated with dysregulation of the alternative pathway of complement activation …

C3 glomerulopathy describes a spectrum of disorders with glomerular pathology associated
with C3 cleavage product deposition and with defective complement action and regulation …

Monoclonal gammopathy is characterized by circulating monoclonal immunoglobulin owing
to clonal proliferation of immunoglobulin-producing B lymphocytes or plasma cells. Clonal …

Abstract 'C3 glomerulopathy'is a recent disease classification comprising several rare types
of glomerulonephritis (GN), including dense deposit disease (DDD), C3 glomerulonephritis …

C3 glomerulopathy refers to those renal lesions characterized histologically by predominant
C3 accumulation within the glomerulus, and pathogenetically by aberrant regulation of the …

The complement (C) cascade is an ancient system of proteins whose primary role is to
initiate and modulate immune responses. During C activation, circulating proteins are …

The vertebrate complement system consists of sequentially interacting proteins that provide
for a rapid and powerful host defense. Nearly 60 proteins comprise three activation …

Since first being documented in ancient times, the relation of inflammation with injury and
disease has evolved in complexity and causality. Early observations supported a cause …

Background Hyperactivity of the alternative complement pathway is the principle defect in
C3 glomerulopathies (C3G). Eculizumab, a monoclonal antibody that binds C5 to prevent …

Membranoproliferative GN represents a pattern of injury seen on light microscopy.
Historically, findings on electron microscopy have been used to further subclassify this …