The current evolutionary biology theory primarily involves genetic alterations and random
DNA sequence mutations to generate the phenotypic variation required for Darwinian …

Cytosine DNA methylation (5mC) is a widespread base modification in eukaryotic genomes
with critical roles in transcriptional regulation. In recent years, our understanding of 5mC has …

DNA methylation is a conserved epigenetic mark that plays important roles in maintaining
genome stability and regulating gene expression. As sessile organisms, plants have …

Epigenetics is the branch of genetics that studies the different mechanisms that influence
gene expression without direct modification of the DNA sequence. An ever-increasing …

BACKGROUND Infertility and pregnancy loss are longstanding problems. Successful
fertilization and high-quality embryos are prerequisites for an ongoing pregnancy. Studies …

A rapidly growing body of literature in several organisms suggests that environmentally-
induced adaptive changes in phenotype can be transmitted across multiple generations …

In eukaryotes with multiple small RNA pathways, the mechanisms that channel RNAs within
specific pathways are unclear. Here, we reveal the reactions that account for channeling in …

Two waves of DNA methylation reprogramming occur during mammalian embryogenesis;
during preimplantation development and during primordial germ cell (PGC) formation …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Ten-eleven translocation (TET) methylcytosine dioxygenases (TET1, TET2, TET3) actively
cause demethylation of 5-methylcytosine (5mC) and produce and safeguard …