Purpose Epigenetic regulation plays critical roles in cancer progression, and high-frequency
mutations or expression variations in epigenetic regulators have been frequently observed …

Although cigarette smoking (CS) and low back pain (LBP) are common worldwide, their
correlations and the mechanisms of action remain unclear. We have shown that excessive …

The regulation of gene transcription by epigenetic modifications is closely related to many
important life processes and is a hot research topic in the post-genomic era. Since the …

Background Methylation of cytosines in DNA (5mC methylation) is a major epigenetic
modification that modulates gene expression and constitutes the basis for mechanisms …

Sex determination systems in vertebrates vary along a continuum from genetic (GSD) to
environmental sex determination (ESD). Individuals that show a sexual phenotype opposite …

Heritable traits are predominantly encoded within genomic DNA, but it is now appreciated
that epigenetic information is also inherited through DNA methylation, histone modifications …

Human health is facing a host of new threats linked to unbalanced diets, including high-
sugar diet (HSD), which contributes to the development of both metabolic and behavioral …

Long noncoding RNAs (lncRNAs), as an important type of RNA encoded in the human
transcriptome, have shown to regulate different genomic processes in human cells, altering …

Transgenerational inheritance from both parental lines can occur by genetic and epigenetic
inheritance. Maternal effects substantially influence offspring survival and fitness. However …

Our understanding of the mechanisms that modulate gene expression in animals is strongly
biased by studying a handful of model species that mainly belong to three groups: Insecta …