In order to meet the high energy demand, a metabolic reprogramming occurs in cancer cells.
Its role is crucial in promoting tumor survival. Among the substrates in demand, oxygen is …

Preeclampsia is a life-threatening pregnancy-associated cardiovascular disorder
characterized by hypertension and proteinuria at 20 weeks of gestation. Though its exact …

The environmental and metabolic pressures in the tumor microenvironment (TME) play a
key role in molding tumor development by impacting the stromal and immune cell fractions …

Tumours require a vascular supply to grow and can achieve this via the expression of pro-
angiogenic growth factors, including members of the vascular endothelial growth factor …

Clear cell renal cell carcinoma (ccRCC) is the most common form of human kidney cancer.
Histological and molecular analyses suggest that ccRCCs have significantly altered …

The ubiquitin–proteasome system (UPS) and ubiquitin-like protein (UBL) conjugation
pathways are integral to cellular protein homeostasis. The growing recognition of the …

Over the past decade, the management of metastatic renal cell carcinoma (RCC) has
undergone rapid evolution, culminating in a significant improvement in prognosis with …

Background MicroRNA regulate mRNA levels in a tissue specific way, either by inducing
degradation of the transcript or by inhibiting translation or transcription. Putative mRNA …

The mammalian target of rapamycin (mTOR) is a major component of the phosphoinositide
3-kinase (PI3K)/AKT signaling pathway that is dysregulated in 50% of all human …

Purpose: Dual inhibition of glucose and glutamine metabolism results in synergistic
anticancer effects in solid tumor models. Telaglenastat, an investigational, small-molecule …