Simple Summary Immunotherapy improved the therapeutic landscape for patients with
advanced cancer diseases. However, many patients do not benefit from immunotherapy …

Autoimmune diseases are usually complex and multifactorial, characterized by aberrant
production of autoreactive immune cells and/or autoantibodies against healthy cells and …

β2 integrins are heterodimeric surface receptors composed of a variable α (CD11a-CD11d)
and a constant β (CD18) subunit and are specifically expressed by leukocytes. The α …

Fibrosis is the result of extracellular matrix protein deposition and remains a leading cause
of death in USA. Despite major advances in recent years, there remains an unmet need to …

Overexpression of interleukin 6 (IL-6) has been proposed to contribute to pulmonary fibrosis
and other fibrotic diseases. However, the regulatory mechanisms and the role of IL-6 in …

Abstract Systemic Sclerosis (SSc) pathogenesis involves multiple immunological, vascular
and fibroproliferative abnormalities that contribute to a severe and complex clinical picture …

Interstitial lung disease (ILD) is a common manifestation of systemic autoimmune diseases
and a leading cause of death in these patients. A proportion of patients with autoimmune …

Fibrosis is becoming increasingly recognized as a major cause of morbidity and mortality in
modern populations, yet still, no targeted antifibrotic therapies have been approved for most …

Treg abnormalities have been implicated in the pathogenesis of systemic sclerosis (SSc).
Treg subpopulations and their cytokines, IL-10 and TGF-β in the peripheral blood of early …

Lysophosphatidic acid (LPA) is the simplest phospholipid found in nature. LPA is mainly
biosynthesized in tissues and cells by autotoxin and PA-PLA1α/PA-PLA1β and is degraded …