Treatment sequencing in resectable lung cancer: the good and the bad of adjuvant versus neoadjuvant therapy
The treatment scenario for patients with resectable non–small cell lung cancer has changed
dramatically with the incorporation of immunotherapy. The introduction of immunotherapy …
dramatically with the incorporation of immunotherapy. The introduction of immunotherapy …
DNA cytosine methylation in plant development
Cytosine bases of the nuclear genome in higher plants are often extensively methylated.
Cytosine methylation has been implicated in the silencing of both transposable elements …
Cytosine methylation has been implicated in the silencing of both transposable elements …
Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility
LE Reinius, N Acevedo, M Joerink, G Pershagen… - PloS one, 2012 - journals.plos.org
Methylation of cytosines at CpG sites is a common epigenetic DNA modification that can be
measured by a large number of methods, now even in a genome-wide manner for hundreds …
measured by a large number of methods, now even in a genome-wide manner for hundreds …
The relationship of DNA methylation with age, gender and genotype in twins and healthy controls
Cytosine-5 methylation within CpG dinucleotides is a potentially important mechanism of
epigenetic influence on human traits and disease. In addition to influences of age and …
epigenetic influence on human traits and disease. In addition to influences of age and …
A longitudinal study of epigenetic variation in twins
DNA methylation is a key epigenetic mechanism involved in the developmental regulation of
gene expression. Alterations in DNA methylation are established contributors to inter …
gene expression. Alterations in DNA methylation are established contributors to inter …
Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters
The role of CpG island methylation in normal development and cell differentiation is of keen
interest, but remains poorly understood. We performed comprehensive DNA methylation …
interest, but remains poorly understood. We performed comprehensive DNA methylation …
An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs)
We report a novel resource (m ethylation p rofiles of D NA, or mPod) for human genome-
wide tissue-specific DNA methylation profiles. mPod consists of three fully integrated parts …
wide tissue-specific DNA methylation profiles. mPod consists of three fully integrated parts …
DNA hypomethylation arises later in prostate cancer progression than CpG island hypermethylation and contributes to metastatic tumor heterogeneity
S Yegnasubramanian, MC Haffner, Y Zhang, B Gurel… - Cancer research, 2008 - AACR
Hypomethylation of CpG dinucleotides in genomic DNA was one of the first somatic
epigenetic alterations discovered in human cancers. DNA hypomethylation is postulated to …
epigenetic alterations discovered in human cancers. DNA hypomethylation is postulated to …
Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver
AL Brunner, DS Johnson, SW Kim, A Valouev… - Genome …, 2009 - genome.cshlp.org
To investigate the role of DNA methylation during human development, we developed
Methyl-seq, a method that assays DNA methylation at more than 90,000 regions throughout …
Methyl-seq, a method that assays DNA methylation at more than 90,000 regions throughout …
Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm
DNA methylation plays key roles in diverse biological processes such as X chromosome
inactivation, transposable element repression, genomic imprinting, and tissue-specific gene …
inactivation, transposable element repression, genomic imprinting, and tissue-specific gene …