Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …
Epigenetics of glioblastoma multiforme: From molecular mechanisms to therapeutic approaches
MS Uddin, A Al Mamun, BS Alghamdi, D Tewari… - Seminars in cancer …, 2022 - Elsevier
Glioblastoma multiforme (GBM) is the most common form of brain cancer and one of the
most aggressive cancers found in humans. Most of the signs and symptoms of GBM can be …
most aggressive cancers found in humans. Most of the signs and symptoms of GBM can be …
[HTML][HTML] Detection of DNA base modifications by deep recurrent neural network on Oxford Nanopore sequencing data
DNA base modifications, such as C5-methylcytosine (5mC) and N6-methyldeoxyadenosine
(6mA), are important types of epigenetic regulations. Short-read bisulfite sequencing and …
(6mA), are important types of epigenetic regulations. Short-read bisulfite sequencing and …
Scaling by shrinking: empowering single-cell'omics' with microfluidic devices
Recent advances in cellular profiling have demonstrated substantial heterogeneity in the
behaviour of cells once deemed'identical', challenging fundamental notions of …
behaviour of cells once deemed'identical', challenging fundamental notions of …
[HTML][HTML] DNA methylation: Precise modulation of chromatin structure and dynamics
DNA methylation plays a vital role in epigenetic regulation in both plants and animals, and
typically occurs at the 5-carbon position of the cytosine pyrimidine ring within the CpG …
typically occurs at the 5-carbon position of the cytosine pyrimidine ring within the CpG …
Cell-type deconvolution from DNA methylation: a review of recent applications
Recent advances in cell-type deconvolution approaches are adding to our understanding of
the biology underlying disease development and progression. DNA methylation (DNAm) …
the biology underlying disease development and progression. DNA methylation (DNAm) …
[HTML][HTML] Strategies for analyzing bisulfite sequencing data
DNA methylation is one of the main epigenetic modifications in the eukaryotic genome; it
has been shown to play a role in cell-type specific regulation of gene expression, and …
has been shown to play a role in cell-type specific regulation of gene expression, and …
[HTML][HTML] DNA methylation validation methods: a coherent review with practical comparison
Š Šestáková, C Šálek, H Remešová - Biological procedures online, 2019 - Springer
Here, we present a practical overview of four commonly used validation methods for DNA
methylation assessment: methylation specific restriction endonucleases (MSRE) analysis …
methylation assessment: methylation specific restriction endonucleases (MSRE) analysis …
Epigenetics, obesity and early-life cadmium or lead exposure
SS Park, DA Skaar, RL Jirtle, C Hoyo - Epigenomics, 2017 - Taylor & Francis
Obesity is a complex and multifactorial disease, which likely comprises multiple subtypes.
Emerging data have linked chemical exposures to obesity. As organismal response to …
Emerging data have linked chemical exposures to obesity. As organismal response to …
[HTML][HTML] Comprehensive cell type decomposition of circulating cell-free DNA with CelFiE
Circulating cell-free DNA (cfDNA) in the bloodstream originates from dying cells and is a
promising noninvasive biomarker for cell death. Here, we propose an algorithm, CelFiE, to …
promising noninvasive biomarker for cell death. Here, we propose an algorithm, CelFiE, to …