A 'fourth wave'of high mortality involving methamphetamine and cocaine use has been
gathering force in the USA. Availability and use of illicit fentanyls are still the major drivers of …

New psychoactive substances (NPS) are a heterogeneous group of substances. They are
associated with a number of health and social harms on an individual and societal level …

The US mortality rate has gone up three years in a row from 2014 to 2017 (Xu, Murphy,
Kochanek, & Arias, 2016; Murphy, Xu, Kochanek, & Arias, 2018; Kochanek, Murphy, Xu, & …

We summarise the evidence for medicinal uses of opioids, harms related to the extramedical
use of, and dependence on, these drugs, and a wide range of interventions used to address …

The current opioid epidemic is one of the most severe public health crisis in US history.
Responding to it has been difficult due to its rapidly changing nature and the severity of its …

Deaths from opioid use are increasing in the US, with a growing proportion due to synthetic
opioids. Until 2013, sporadic outbreaks of fentanyl and fentanyl analogs contaminating the …

Psychoactive substances with chemical structures or pharmacological profiles that are
similar to traditional drugs of abuse continue to emerge on the recreational drug market …

Sharp increases in opioid overdose deaths since 2013 are partly explained by the
introduction of illicitly manufactured fentanyl into the heroin market. Outbreaks related to …

Overdose deaths are often viewed as the leading edge of the opioid epidemic which has
gripped the United States over the past two decades (Skolnick, 2018a). This emphasis is …

Background Prevalence of fentanyl-laced counterfeit prescription pills has been increasing
in the US, possibly placing a wider population at risk for unintentional exposure. We aimed …