It remains unclear why acute depletion of CTCF (CCCTC-binding factor) and cohesin only
marginally affects expression of most genes despite substantially perturbing three …

Zygotic genome activation (ZGA) marks the beginning of the embryonic program for a
totipotent embryo, which gives rise to the inner cell mass (ICM) where pluripotent epiblast …

Many eukaryotic transcription factors (TF) form homodimer or heterodimer complexes to
regulate gene expression. Dimerization of BASIC LEUCINE ZIPPER (bZIP) TFs are critical …

Pioneer transcription factors (TFs), such as OCT4 and SOX2, play crucial roles in
pluripotency regulation. However, the master TF-governed pluripotency regulatory circuitry …

Polyploidization is a major driver of genome diversification and environmental adaptation.
However, the merger of different genomes may result in genomic conflicts, raising a major …

During the first lineage segregation, a mammalian totipotent embryo differentiates into the
inner cell mass (ICM) and trophectoderm (TE). However, how transcription factors (TFs) …

Acute pancreatitis and hyperamylasemia are often seen in patients with acute liver failure
(ALF). However, the underlying mechanisms remain elusive. This study describes …

It remains unclear why acute depletion of CTCF and cohesin only marginally affects
expression of most genes despite substantially perturbing 3D genome folding at the level of …

High-temperature (HT) stress causes male sterility in crops, thus decreasing yields. To
explore the possible contribution of histone modifications to male fertility under HT …

Dasypyrum villosum is one of the most valuable gene resources in wheat improvement,
especially for disease resistance. The mining of favorable genes from D. villosum is …