Histone lysine methylation has emerged as a critical player in the regulation of gene
expression, cell cycle, genome stability, and nuclear architecture. Over the past decade, a …

Aberrant gene function and altered patterns of gene expression are key features of cancer.
Growing evidence shows that acquired epigenetic abnormalities participate with genetic …

The gene encoding ARID1A, a chromatin remodeler, shows one of the highest mutation
rates across many cancer types. Notably, ARID1A is mutated in over 50% of ovarian clear …

The formation of R-loops is a natural consequence of the transcription process, caused by
invasion of the DNA duplex by nascent transcripts. These structures have been considered …

Histone lysine methylation has important roles in the organization of chromatin domains and
the regulation of gene expression. To analyze its function and modulate its activity, we …

Alternatively activated (M2) macrophages play critical roles in diverse chronic diseases,
including parasite infections, cancer, and allergic responses. However, little is known about …

Recent studies demonstrated that histone methylation is not static but is dynamically
regulated by histone methyltransferases and the newly discovered histone demethylases …

Epigenetic modifications, such as acetylation, phosphorylation, methylation, ubiquitination,
and ADP ribosylation, of the highly conserved core histones, H2A, H2B, H3, and H4 …

Endometriosis is a common gynecologic disorder with an enigmatic etiopathogenesis.
Although it has been proposed that endometriosis is a hormonal disease, an autoimmune …

Methylation of DNA and lysine 9 of histone H3 (H3K9) are well‐conserved epigenetic marks
for transcriptional silencing. Although H3K9 methylation directs DNA methylation in …