The development of animal embryos is initially directed by maternal gene products. Then,
during the maternal-to-zygotic transition (MZT), developmental control is handed to the …

DNA methylation involves the addition of a methyl group to the fifth carbon of the pyrimidine
cytosine ring (5-methylcytosine, 5mC). 5mC is widespread in vertebrate genomes where it is …

We have produced an mRNA expression time course of zebrafish development across 18
time points from 1 cell to 5 days post-fertilisation sampling individual and pools of embryos …

The zebrafish (Danio rerio) has been widely used in the study of human disease and
development, and about 70% of the protein-coding genes are conserved between the two …

To regulate expression, enhancers must come in proximity to their target gene. However, the
relationship between the timing of enhancer–promoter (E–P) proximity and activity remains …

Poised enhancers (PEs) represent a genetically distinct set of distal regulatory elements that
control the expression of major developmental genes. Before becoming activated in …

While the field of epigenetics is increasingly recognized to contribute to the emergence of
phenotypes in mammalian research models across different developmental and …

The spatial organization of chromosomes is critical in establishing gene expression
programs. We generated in situ Hi-C maps throughout zebrafish development to gain insight …

In the mammalian heart a conduction system of nodes and conducting cells generates and
transduces the electrical signals evoking myocardial contractions. Specialized pacemaker …

CRISPR-Cas9 technology is routinely applied for targeted mutagenesis in model organisms
and cell lines. Recent studies indicate that the prokaryotic CRISPR-Cas9 system is affected …