Asexual ploidy shifts, which describe changes in complete sets of chromosomes via a
nonsexual reproductive cycle, are widespread in nature. For example, increased ploidy …

Fungi often adapt to environmental stress by altering their size, shape, or rate of cell division.
These morphological changes require reorganization of the cell wall, a structural feature …

Bacterial persisters, a subpopulation of genetically susceptible cells that are normally
dormant and tolerant to bactericides, have been studied extensively because of their clinical …

Cryptococcosis is a potentially lethal fungal infection of humans caused by organisms within
the Cryptococcus neoformans/gattii species complex. Whilst C. neoformans is a relatively …

Genome copy number variation occurs during each mitotic and meiotic cycle and it is crucial
for organisms to maintain their natural ploidy. Defects in ploidy transitions can lead to …

Many successful pathogens cause latent infections, remaining dormant within the host for
years but retaining the ability to reactivate to cause symptomatic disease. The human …

Cellular development is orchestrated by evolutionarily conserved signaling pathways, which
are often pleiotropic and involve intra-and interpathway epistatic interactions that form …

Opportunistic pathogens of the anamorphic genus Cryptococcus are unique considering
their virulence factors that in the context of pathogenesis allowed them to achieve …

Fungal pathogens often undergo morphological switches, including cell size changes, to
adapt to the host environment and cause disease. The pathogenic yeast Cryptococcus …

Cryptococcus neoformans is an opportunistic, human fungal pathogen which undergoes
fascinating switches in cell cycle control and ploidy when it encounters stressful …