Anti-epileptic drugs (AEDs) are an important group of drugs of several generations, ranging
from the oldest phenobarbital (1912) to the most recent cenobamate (2019). Cannabidiol …

Seizures are common in neonates, but there is substantial management variability. The
Neonatal Task Force of the International League Against Epilepsy (ILAE) developed …

Therapeutic hypothermia (TH) is standard treatment for neonates (≥ 36 weeks) with
perinatal asphyxia (PA) and hypoxic–ischemic encephalopathy. TH reduces mortality and …

Background Neonatal hypoxic ischaemic encephalopathy due to perinatal asphyxia, can
result in severe neurodevelopmental disability or mortality. Hypothermia is at present the …

Pharmacotherapy in pediatric patients is challenging in view of the maturation of organ
systems and processes that affect pharmacokinetics and pharmacodynamics. Especially for …

Introduction Perinatal asphyxia (PA) still causes significant morbidity and mortality.
Therapeutic hypothermia (TH) is the only effective therapy for neonates with moderate to …

The volume of distribution at steady state (Vss) in neonates is still often estimated through
isometric scaling from adult values, disregarding developmental changes beyond body …

Objectives We aimed to evaluate 1) whether sedation analgesia (SA) used during
therapeutic hypothermia (TH) is efficient to support the well-being of neonates with hypoxic …

Background Newborn infants undergoing therapeutic hypothermia (TH) are exposed to
multiple painful and stressful procedures. The aim of this systematic review was to assess …

Neonatal encephalopathy (NE) is the most common etiology of acute neonatal seizures–
about half of neonates treated with therapeutic hypothermia for NE have EEG-confirmed …