Background Estimation of intracranial pressure (ICP) may be helpful in the management of
neurological critically ill patients. It has been shown that ultrasonography of the optic nerve …

Background The concentration of oxygen in air remains constant at 21% regardless of the
altitude. However, the partial pressure of oxygen decreases with increasing altitude …

High-altitude cerebral edema (HACE) and acute mountain sickness (AMS) are
neuropathologies associated with rapid exposure to hypoxia. However, speculation remains …

Monitoring of intracranial pressure (ICP) is invaluable in the management of neurosurgical
and neurological critically ill patients. Invasive measurement of ventricular or parenchymal …

Ethnopharmacological relevance Rhodiola crenulata, a traditional Tibetan medicine, has
shown promise in the treatment of hypobaric hypoxia (HH)-induced brain injury. However …

After ascent to high altitude (≥ 2500 m), the inability of the human body to adapt to the
hypobaric and hypoxia environment can induce tissue hypoxia, then a series of high altitude …

The blood-brain barrier (BBB) is located at the interface between the vascular system and
the brain parenchyma, and is responsible for communication with systemic circulation and …

Background When lowlanders rapidly ascend to altitudes> 2500 m, they may develop acute
mountain sickness (AMS). The individual susceptibility, ascending velocity, time spent at …

Rapid ascent to high altitude commonly results in acute mountain sickness, and on occasion
potentially fatal high-altitude cerebral edema. The exact pathophysiological mechanisms …

The pathophysiology of acute mountain sickness and high-altitude cerebral edema, the
cerebral forms of high-altitude illness, remain uncertain and controversial. Persistently …