Regulation of tumor cell migration and invasion by the H19/let-7 axis is antagonized by metformin-induced DNA methylation
The imprinted, developmentally regulated H19 long noncoding RNA has been implicated in
the pathogenesis of diverse human cancers, but the underlying mechanisms have remained …
the pathogenesis of diverse human cancers, but the underlying mechanisms have remained …
DNA methylation and schizophrenia: current literature and future perspective
Schizophrenia is a neuropsychiatric disorder characterized by dissociation of thoughts, idea,
identity, and emotions. It has no central pathophysiological mechanism and precise …
identity, and emotions. It has no central pathophysiological mechanism and precise …
An epigenetic framework for neurodevelopmental disorders: from pathogenesis to potential therapy
MJ Millan - Neuropharmacology, 2013 - Elsevier
Neurodevelopmental disorders (NDDs) are characterized by aberrant and delayed early-life
development of the brain, leading to deficits in language, cognition, motor behaviour and …
development of the brain, leading to deficits in language, cognition, motor behaviour and …
Genome-wide DNA methylation changes in a mouse model of infection-mediated neurodevelopmental disorders
Background Prenatal exposure to infectious or inflammatory insults increases the risk of
neurodevelopmental disorders. Using a well-established mouse model of prenatal viral-like …
neurodevelopmental disorders. Using a well-established mouse model of prenatal viral-like …
Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders
Ageing is the main risk factor for human neurological disorders. Among the diverse
molecular pathways that govern ageing, epigenetics can guide age-associated decline in …
molecular pathways that govern ageing, epigenetics can guide age-associated decline in …
Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer's disease: An integrative review
MJ Millan - Progress in neurobiology, 2017 - Elsevier
The human genome encodes a vast repertoire of protein non-coding RNAs (ncRNA), some
specific to the brain. MicroRNAs, which interfere with the translation of target mRNAs, are of …
specific to the brain. MicroRNAs, which interfere with the translation of target mRNAs, are of …
Dynamic expression of DNA methyltransferases (DNMTs) in oocytes and early embryos
F Uysal, G Akkoyunlu, S Ozturk - Biochimie, 2015 - Elsevier
Epigenetic mechanisms play critical roles in oogenesis and early embryo development in
mammals. One of these epigenetic mechanisms, DNA methylation is accomplished through …
mammals. One of these epigenetic mechanisms, DNA methylation is accomplished through …
Brain-derived neurotrophic factor epigenetic modifications associated with schizophrenia-like phenotype induced by prenatal stress in mice
E Dong, SG Dzitoyeva, F Matrisciano, P Tueting… - Biological …, 2015 - Elsevier
Background Prenatal stress (PRS) is considered a risk factor for several
neurodevelopmental disorders including schizophrenia (SZ). An animal model involving …
neurodevelopmental disorders including schizophrenia (SZ). An animal model involving …
Reelin through the years: From brain development to inflammation
Reelin was originally identified as a regulator of neuronal migration and synaptic function,
but its non-neuronal functions have received far less attention. Reelin participates in organ …
but its non-neuronal functions have received far less attention. Reelin participates in organ …
Learning from the past and looking to the future: emerging perspectives for improving the treatment of psychiatric disorders
MJ Millan, GM Goodwin, A Meyer-Lindenberg… - European …, 2015 - Elsevier
Modern neuropsychopharmacology commenced in the 1950s with the serendipitous
discovery of first-generation antipsychotics and antidepressants which were therapeutically …
discovery of first-generation antipsychotics and antidepressants which were therapeutically …