Merging data from genetic and epigenetic approaches to better understand autistic spectrum disorder
DR Grayson, A Guidotti - Epigenomics, 2016 - Taylor & Francis
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that is
characterized by a wide range of cognitive and behavioral abnormalities. Genetic research …
characterized by a wide range of cognitive and behavioral abnormalities. Genetic research …
[HTML][HTML] Brain iron loading impairs DNA methylation and alters GABAergic function in mice
Iron deficiency is closely associated with altered GABA metabolism and affective behavior.
While mutation in the hemochromatosis (HFE) gene disrupts iron homeostasis and promotes …
While mutation in the hemochromatosis (HFE) gene disrupts iron homeostasis and promotes …
Conserved chromosome 2q31 conformations are associated with transcriptional regulation of GAD1 GABA synthesis enzyme and altered in prefrontal cortex of …
Little is known about chromosomal loopings involving proximal promoter and distal
enhancer elements regulating GABAergic gene expression, including changes in …
enhancer elements regulating GABAergic gene expression, including changes in …
Hydroxymethylation and its potential implication in DNA repair system: a review and future perspectives
Abstract The 5-hydroxymethylcytosine (5-hmC) is known to exist as a predictive indicator for
a variety of cancers, neurological abnormalities and other perilous diseases. The precursor …
a variety of cancers, neurological abnormalities and other perilous diseases. The precursor …
Emerging Role of One-Carbon Metabolism and DNA Methylation Enrichment on δ-Containing GABAA Receptor Expression in the Cerebellum of Subjects with …
Background Cerebellum is an area of the brain particularly sensitive to the effects of acute
and chronic alcohol consumption. Alcohol exposure decreases cerebellar Purkinje cell …
and chronic alcohol consumption. Alcohol exposure decreases cerebellar Purkinje cell …
Transcriptional regulation of GAD1 GABA synthesis gene in the prefrontal cortex of subjects with schizophrenia
Expression of GAD1 GABA synthesis enzyme is highly regulated by neuronal activity and
reaches mature levels in the prefrontal cortex not before adolescence. A significant portion …
reaches mature levels in the prefrontal cortex not before adolescence. A significant portion …
Kinetic Analysis and Quantification of [11C]Martinostat for in Vivo HDAC Imaging of the Brain
HY Wey, C Wang, FA Schroeder, J Logan… - ACS chemical …, 2015 - ACS Publications
Epigenetic mechanisms mediated by histone deacetylases (HDACs) have been implicated
in a wide-range of CNS disorders and may offer new therapeutic opportunities. In vivo …
in a wide-range of CNS disorders and may offer new therapeutic opportunities. In vivo …
Significant effect of valproate augmentation therapy in patients with schizophrenia: a meta-analysis study
Valproate is an anticonvulsant, which is also widely used for treating psychiatric disorders.
Some clinical trials have demonstrated benefits of valproate augmentation therapy in …
Some clinical trials have demonstrated benefits of valproate augmentation therapy in …
Effects of DNA methylation inhibitors and conventional antidepressants on mice behaviour and brain DNA methylation levels
ObjectiveStress increases DNA methylation and decreases the expression of genes
involved in neural plasticity, while treatment with DNA methyltransferase inhibitors (DNMTi) …
involved in neural plasticity, while treatment with DNA methyltransferase inhibitors (DNMTi) …
DNA methylation and histone modifications associated with antipsychotic treatment: a systematic review
Antipsychotic medications are essential when treating schizophrenia spectrum and other
psychotic disorders, but the efficacy and tolerability of these medications vary from person to …
psychotic disorders, but the efficacy and tolerability of these medications vary from person to …