Despite the success of genome-wide association studies (GWASs) in identifying loci
associated with common diseases, a substantial proportion of the causality remains …

Formation of skeletal muscle fibers (myogenesis) during development and after tissue injury
in the adult constitutes an excellent paradigm to investigate the mechanisms whereby …

Simple Summary Nutrition affects all interactions of the body, especially the genome and the
expression of genes. All organisms are always feeding, and life is not possible without …

Recent findings in epigenetics shed new light on the regulation of gene expression in the
central nervous system (CNS) during stress. The most frequently studied epigenetic …

Differentiation-related DNA methylation is receiving increasing attention, partly owing to
new, whole-genome analyses. These revealed that cell type-specific differential methylation …

The mammalian intestinal epithelium has a unique organization in which crypts harboring
stem cells produce progenitors and finally clonal populations of differentiated cells …

Since the seminal discovery of the cell-fate regulator Myod, studies in skeletal myogenesis
have inspired the search for cell-fate regulators of similar potential in other tissues and …

In response to muscle injury, muscle stem cells integrate environmental cues in the
damaged tissue to mediate regeneration. These environmental cues are tightly regulated to …

Tissue‐specific transcriptional activators initiate differentiation towards specialized cell types
by inducing chromatin modifications permissive for transcription at target loci, through the …

Sequence motifs are short, recurring patterns in DNA that can mediate sequence-specific
binding for proteins such as transcription factors or DNA modifying enzymes. The androgen …