DNA methylation is a stable epigenetic modification that contributes to the spatiotemporal
regulation of gene expression. The manner in which DNA methylation contributes to …

Cells of a multicellular organism are genetically homogeneous but structurally and
functionally heterogeneous owing to the differential expression of genes. Many of these …

Pancreatic cancer is often detected late, when curative therapies are no longer possible.
Here, we present non-invasive detection of pancreatic ductal adenocarcinoma (PDAC) by 5 …

DNA methylation is an epigenetic mechanism for gene silencing engaged by DNA
methyltransferase (Dnmt)-catalyzed methyl group transfer to cytosine residues in gene …

Approximately 45% of the human genome is composed of transposable elements (TEs).
Expression of these elements is tightly regulated during normal development. TEs may be …

Atherosclerosis, which is the most common chronic disease of the coronary artery,
constitutes a vascular pathology induced by inflammation and plaque accumulation within …

DNA methylation plays an important role in the maintenance of genomic stability. Ten-
eleven translocation proteins (TETs) are a family of iron (Fe2+) and α-KG-dependent …

Histone crotonylation is a newly identified epigenetic modification that has a pronounced
ability to regulate gene expression. It belongs to an expanding group of short chain lysine …

As expansions of CGG short tandem repeats (STRs) are established as the genetic etiology
of many neurodevelopmental disorders, we aimed to elucidate the inheritance patterns and …

FOXA1 and FOXA2, members of the forkhead transcription factor family, are critical for
epithelial differentiation in many endoderm-derived organs, including the pancreas …