Transgenerational effects of paternal exposures: the role of germline de novo mutations
H Dehghanbanadaki, M Jimbo, K Fendereski… - …, 2024 - Wiley Online Library
Germline de novo mutations (DNMs) refer to spontaneous mutations arising during
gametogenesis, resulting in genetic changes within germ cells that are subsequently …
gametogenesis, resulting in genetic changes within germ cells that are subsequently …
Frequency and spectrum of mutations in human sperm measured using duplex sequencing correlate with trio-based de novo mutation analyses
J Axelsson, D LeBlanc, H Shojaeisaadi, MJ Meier… - medRxiv, 2024 - medrxiv.org
De novo mutations (DNMs) are drivers of genetic disorders. However, the study of DNMs is
hampered by technological limitations preventing accurate quantification of ultra-rare …
hampered by technological limitations preventing accurate quantification of ultra-rare …
Living birth following preimplantation genetic testing for monogenic disorders to prevent low-level germline mosaicism related Nicolaides–Baraitser syndrome
J Pan, J Li, S Chen, C Xu, H Huang, L Jin - Frontiers in Genetics, 2022 - frontiersin.org
Objective: Paternal sperm mosaicism has few consequences for fathers for mutations being
restricted to sperm. However, it could potentially underlie severe sporadic disease in their …
restricted to sperm. However, it could potentially underlie severe sporadic disease in their …
Non-neutral clonal selection and its potential role in mammalian germline stem cell dysfunction with advancing age
The concept of natural selection, or" survival of the fittest", refers to an evolutionary process
in nature whereby traits emerge in individuals of a population through random gene …
in nature whereby traits emerge in individuals of a population through random gene …