Abstract Transient Receptor Potential (TRP) channels are evolutionarily conserved integral
membrane proteins. The mammalian TRP superfamily of ion channels consists of 28 cation …

Forces that are associated with blood flow are major determinants of vascular
morphogenesis and physiology. Blood flow is crucial for blood vessel development during …

Several proteins implicated in the pathogenesis of polycystic kidney disease (PKD) localize
to cilia. Furthermore, cilia are malformed in mice with PKD with mutations in TgN737Rpw …

The mammalian cilium protrudes from the apical/lumenal surface of polarized cells and acts
as a sensor of environmental cues. Numerous developmental disorders and pathological …

Polycystic kidney diseases are inherited renal disorders due mainly to mutations in genes
that regulate the development and function of cells that line renal tubules. This review …

Polycystic kidney disease (PKD) is a leading cause of ESRD worldwide. In PKD, excessive
cell proliferation and fluid secretion, pathogenic interactions of mutated epithelial cells with …

Cyclic mechanical strain produced by pulsatile blood flow regulates the orientation of
endothelial cells lining blood vessels and influences critical processes such as …

The murine autosomal recessive juvenile cystic kidney (jck) mutation results in polycystic
kidney disease. We have identified in jck mice a mutation in Nek8, a novel and highly …

Polycystic kidney disease (PKD) includes a group of disorders that are characterized by the
presence of cysts in the kidney and other organs, including the pancreas. Here we show that …

Functional analysis of polycystin-1, the product of the gene most frequently mutated in
autosomal dominant polycystic kidney disease, has revealed that this protein is involved in …