Next-generation sequencing has allowed identification of millions of somatic mutations and
epigenetic changes in cancer cells. A key challenge in interpreting cancer genomes and …

DNA hypomethylation was the initial epigenetic abnormality recognized in human tumors.
However, for several decades after its independent discovery by two laboratories in 1983, it …

The term “epigenetics” refers to modifications in gene expression caused by heritable, but
potentially reversible, changes in DNA methylation and chromatin structure. Given the fact …

Aberrant promoter methylation of tumor suppressor genes has not been fully investigated in
pediatric tumors. Therefore, we examined the methylation status of nine genes (p16 INK4A …

It is well known that a variety of genetic changes influence the development and progression
of cancer. These changes may result from inherited or spontaneous mutations that are not …

Medulloblastoma is frequently disseminated throughout the central nervous system by the
time of diagnosis. Conventional therapeutic approaches have not reduced the high mortality …

Aberrant methylation of CpG islands and genomic deletion are two predominant
mechanisms of gene inactivation in tumorigenesis, but the extent to which they interact is …

Survival rates of pediatric brain tumor patients have significantly improved over the years
due to developments in diagnostic techniques, neurosurgery, chemotherapy, radiotherapy …

Medulloblastoma (MB) is the most common childhood malignant brain tumor, accounting for
approximately 20% of all pediatric central nervous system tumors. Current standard …

Research in cancer epigenomics is driven by the development of novel technologies and
the utilization of model organisms ranging from yeasts to plants to vertebrates. For decades …