Abdominal aortic aneurysm (AAA) rupture is an important cause of death in adults. Currently,
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …

Aortic aneurysm is a vascular disease whereby the ECM (extracellular matrix) of a blood
vessel degenerates, leading to dilation and eventually vessel wall rupture. Recently, it was …

Despite declining incidence and mortality rates in many countries, the abdominal aortic
aneurysm (AAA) continues to represent a life-threatening cardiovascular condition with an …

An abdominal aortic aneurysm (AAA) is a localized dilatation of the infrarenal aorta. AAA is a
multifactorial disease, and genetic and environmental factors play a part; smoking, male sex …

Atherothrombosis remains one of the main causes of morbidity and mortality in the western
countries. Human atherothrombotic disease begins early in life in relation to circulating lipid …

The biomechanical factors that result from the haemodynamic load on the cardiovascular
system are a common denominator of several vascular pathologies. Thickening and …

A non-resolving inflammation results in a chronic inflammatory response, characteristic of
atherosclerosis, abdominal aortic aneurysms and several other cardiovascular diseases …

Vascular smooth muscle cells (vSMCs) play a crucial role in both the pathogenesis of
Aneurysms and Dissections of the ascending thoracic aorta (TAAD) in humans and in the …

Human abdominal aortic aneurysm (AAA) pathophysiology is not yet completely understood.
In conductance arteries, the insoluble extracellular matrix, synthesized by vascular smooth …

Blood vessels are vital to sustain life in all vertebrates. While it is known that mural cells
(pericytes and smooth muscle cells) regulate vascular integrity, the contribution of other cell …