Molecular mechanisms of transgenerational epigenetic inheritance
MH Fitz-James, G Cavalli - Nature Reviews Genetics, 2022 - nature.com
Increasing evidence indicates that non-DNA sequence-based epigenetic information can be
inherited across several generations in organisms ranging from yeast to plants to humans …
inherited across several generations in organisms ranging from yeast to plants to humans …
Molecular responses to acute exercise and their relevance for adaptations in skeletal muscle to exercise training
B Egan, AP Sharples - Physiological Reviews, 2023 - journals.physiology.org
Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …
exercise training are a potent stimulus for physiological adaptation in many organs …
Pathophysiology of type 2 diabetes mellitus
U Galicia-Garcia, A Benito-Vicente, S Jebari… - International journal of …, 2020 - mdpi.com
Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused
by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and …
by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and …
EDC-2: the Endocrine Society's second scientific statement on endocrine-disrupting chemicals
Abstract The Endocrine Society's first Scientific Statement in 2009 provided a wake-up call to
the scientific community about how environmental endocrine-disrupting chemicals (EDCs) …
the scientific community about how environmental endocrine-disrupting chemicals (EDCs) …
Sex differences in vulnerability and resilience to stress across the life span
GE Hodes, CN Epperson - Biological psychiatry, 2019 - Elsevier
Susceptibility and resilience to stress depend on 1) the timing of the exposure with respect to
development, 2) the time across the life span at which effects are measured, and 3) the …
development, 2) the time across the life span at which effects are measured, and 3) the …
High-intensity exercise and mitochondrial biogenesis: current controversies and future research directions
It is well established that different types of exercise can provide a powerful stimulus for
mitochondrial biogenesis. However, there are conflicting findings in the literature, and a …
mitochondrial biogenesis. However, there are conflicting findings in the literature, and a …
Human skeletal muscle possesses an epigenetic memory of hypertrophy
It is unknown if adult human skeletal muscle has an epigenetic memory of earlier encounters
with growth. We report, for the first time in humans, genome-wide DNA methylation (850,000 …
with growth. We report, for the first time in humans, genome-wide DNA methylation (850,000 …
Methyl-CpG-binding domain proteins: readers of the epigenome
How DNA methylation is interpreted and influences genome regulation remains largely
unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates …
unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates …
CpG islands and the regulation of transcription
Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate
significantly from the average genomic pattern by being GC-rich, CpG-rich, and …
significantly from the average genomic pattern by being GC-rich, CpG-rich, and …
Cancer genetics and epigenetics: two sides of the same coin?
JS You, PA Jones - Cancer cell, 2012 - cell.com
Epigenetic and genetic alterations have long been thought of as two separate mechanisms
participating in carcinogenesis. A recent outcome of whole exome sequencing of thousands …
participating in carcinogenesis. A recent outcome of whole exome sequencing of thousands …