The gut microbiota contributes to host physiology through the production of a myriad of
metabolites. These metabolites exert their effects within the host as signalling molecules and …

Many bacterial pathogens can permanently colonize their host and establish either chronic
or recurrent infections that the immune system and antimicrobial therapies fail to eradicate …

The discovery of N6-methyldeoxyadenine (6mA) across eukaryotes led to a search for
additional epigenetic mechanisms. However, some studies have highlighted confounding …

An increasing number of studies have reported that bacterial DNA methylation has important
functions beyond the roles in restriction-modification systems, including the ability of …

In 1961, Jacob and Monod proposed the operon model of gene regulation. At the model's
core was the modular assembly of regulators, operators, and structural genes. To illustrate …

Chemical modifications to nucleic acids occur across the kingdoms of life and carry
important regulatory information. Reliable high-resolution mapping of these modifications is …

The pursuit of highly sensitive and specific cancer diagnostics based on cell‐free nucleic
acids isolated from minimally invasive liquid biopsies has been an area of intense research …

Since the nucleoid was isolated from bacteria in the 1970s, two fundamental questions
emerged and are still in the spotlight: how bacteria organize their chromosomes to fit inside …

Vitamin B-12 deficiency is a major public health problem affecting individuals across the
lifespan, with known hematological, neurological, and obstetric consequences. Emerging …

The epigenetic clock is defined by the DNA methylation (DNAm) level and has been
extensively applied to distinguish biological age from chronological age. Aging-related …