The evaluation and follow up of liver fibrosis and cirrhosis have been traditionally performed
by liver biopsy. However, during the last 20 years, it has become evident that this “gold …

Alcoholic liver disease (ALD) is characterized by steatosis and upregulation of
proinflammatory cytokines, including IL-1β. IL-1β, type I IL-1 receptor (IL-1R1), and IL-1 …

Underlying the pathogenesis of chronic disease is the state of oxidative stress. Oxidative
stress is an imbalance in oxidant and antioxidant levels. If an overproduction of oxidants …

In alcohol-induced liver disease (ALD) and in non-alcoholic fatty liver disease (NAFLD),
there are abnormal accumulations of fat in the liver. This phenomenon may be related to …

BACKGROUND & AIMS: Alcoholic hepatitis is a cause of major morbidity and mortality that
lacks effective therapies. Both experimental and clinical evidence indicate that the …

Fibrosis is a hallmark histologic event of chronic liver diseases and is characterized by the
excessive accumulation and reorganization of the extracellular matrix (ECM). The gold …

Liver disease is a significant health problem worldwide with mortality reaching around 2
million deaths a year. Non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease …

Excessive alcohol consumption leads to damage to the organs of the body. More
importantly, the liver is majorly affected organ upon alcohol consumption for most of the …

CZE and CIEF of proteins have preceded, and accompanied, the birth of proteomics.
Although they might not be fully exploited in massive proteomic analyses (especially those …

Clinical vignette A 33-year-old Caucasian male was admitted to hospital with recent onset of
jaundice of 2–3 weeks duration. He reported heavy use of alcohol for the last 10 years with …