Despite much recent progress, prostate cancer continues to represent a major cause of
cancer-related mortality and morbidity in men. Since early studies on the role of the …

Prostate cancer ranks fifth in cancer-related mortality in men worldwide. DNA damage is
implicated in cancer and DNA damage response (DDR) pathways are in place against this …

Rosa species, rose hips, are widespread wild plants that have been traditionally used as
medicinal compounds for the treatment of a wide variety of diseases. The therapeutic …

The path to the discovery of suberoylanilide hydroxamic acid (SAHA, vorinostat) began over
three decades ago with our studies designed to understand why dimethylsulfoxide causes …

High activity of histone deacetylases (HDACs) causes epigenetic alterations associated with
malignant cell behaviour. Consequently, HDAC inhibitors have entered late-phase clinical …

Prostate cancer (PCa) is the most prevalent cancer with a high mortality rate. The early and
accurate detection of PCa can significantly reduce mortality and saves lives. Hence, the …

BACKGROUND The clinical success of the nucleoside analogs 5‐aza‐cytidine (5‐azaC)
and 5‐aza‐2′ deoxycytidine (5‐aza‐dC) as DNA methyltransferase (DNMT) inhibitors has …

Epigenetic silencing of gluthathione‐S‐transferase pi (GSTP1) is recognized as being a
molecular hallmark of human prostate cancer. We investigated the effects of green tea …

Beginning with precursor lesions, aberrant DNA methylation marks the entire spectrum of
prostate cancer progression. We mapped the global DNA methylation patterns in select …

Translocations fusing the strong androgen-responsive gene, TMPRSS2, with ERG or other
oncogenic ETS factors may facilitate prostate cancer development. Here, we studied 18 …