There is a great need to develop better mechanism-based therapies for prostate cancer. In
this investigation, we studied four human prostate cancer cell lines, LNCaP, DU145, LAPC4 …

Most recent investigations into cancer etiology have identified a key role played by
epigenetics. Specifically, aberrant DNA and histone modifications which silence tumor …

Epigenetic modifications play a key role in the patho-physiology of prostate cancer. Histone
deacetylases (HDACs) play major roles in prostate cancer progression. HDACs are part of a …

DNA hypermethylation is a common epigenetic alteration in human prostate cancer and is
considered to contribute to development of this disease. Accumulating data suggest that …

BACKGROUND Prostate cancer is the most commonly diagnosed cancer among men in
North America and is a leading cause of death. Standard treatments include androgen …

Prostate cancer (PCa) is a multifactorial disease with an unclear etiology. Due to its high
prevalence, long latency, and slow progression, PCa is an ideal target for chemoprevention …

The role of epigenetic alterations in various human chronic diseases has gained increasing
attention and has resulted in a paradigm shift in our understanding of disease susceptibility …

Prostate cancer (PC) is the most commonly diagnosed neoplasm and the third most
common cause of cancer-related death amongst men in the Western world. PC is a clinically …

Prostate cancer (PCa) is the most prevalent urological cancer that affects aging men in
South Africa, and mechanisms underlying prostate tumorigenesis remain elusive. Research …

Onset of castration-resistance prostate cancer (CRPC) after long-term androgen deprivation
therapy remains a major obstacle in the treatment of prostate cancer. The peptidylarginine …