Hepatocellular carcinoma mechanisms associated with chronic HCV infection and the impact of direct-acting antiviral treatment
S Dash, Y Aydin, KE Widmer… - Journal of hepatocellular …, 2020 - Taylor & Francis
Hepatitis C virus (HCV) infection is the major risk factor for liver cirrhosis and hepatocellular
carcinoma (HCC). The mechanisms of HCC initiation, growth, and metastasis appear to be …
carcinoma (HCC). The mechanisms of HCC initiation, growth, and metastasis appear to be …
Epigenetics in liver disease: from biology to therapeutics
T Hardy, DA Mann - Gut, 2016 - gut.bmj.com
Knowledge of the fundamental epigenetic mechanisms governing gene expression and
cellular phenotype are sufficiently advanced that novel insights into the epigenetic control of …
cellular phenotype are sufficiently advanced that novel insights into the epigenetic control of …
[HTML][HTML] CRISPR-dCas9 mediated TET1 targeting for selective DNA demethylation at BRCA1 promoter
DNA hypermethylation at the promoter of tumour-suppressor genes is tightly correlated with
their transcriptional repression and recognized as the hallmark of majority of cancers …
their transcriptional repression and recognized as the hallmark of majority of cancers …
[PDF][PDF] Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation
Hepatocellular adenomas (HCA) are benign liver tumors predominantly developed in
women using oral contraceptives. Here, exome sequencing identified recurrent somatic FRK …
women using oral contraceptives. Here, exome sequencing identified recurrent somatic FRK …
Epigenetic mechanisms in anti‐cancer actions of bioactive food components–the implications in cancer prevention
B Stefanska, H Karlic, F Varga… - British journal of …, 2012 - Wiley Online Library
The hallmarks of carcinogenesis are aberrations in gene expression and protein function
caused by both genetic and epigenetic modifications. Epigenetics refers to the changes in …
caused by both genetic and epigenetic modifications. Epigenetics refers to the changes in …
Liver cancer: therapeutic challenges and the importance of experimental models
M Galicia-Moreno, JA Silva-Gomez… - Canadian Journal of …, 2021 - Wiley Online Library
Liver cancer is one of the main causes of death related to cancer worldwide; its etiology is
related with infections by C or B hepatitis virus, alcohol consumption, smoking, obesity …
related with infections by C or B hepatitis virus, alcohol consumption, smoking, obesity …
Identification of core genes and outcomes in hepatocellular carcinoma by bioinformatics analysis
S Shen, J Kong, Y Qiu, X Yang… - Journal of cellular …, 2019 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the most common malignant liver disease in the world.
However, the mechanistic relationships among various genes and signaling pathways are …
However, the mechanistic relationships among various genes and signaling pathways are …
Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma
IP Pogribny, I Rusyn - Cancer letters, 2014 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most lethal and prevalent cancers in humans.
The molecular mechanisms leading to the development of HCC are extremely complicated …
The molecular mechanisms leading to the development of HCC are extremely complicated …
Genome-wide study of hypomethylated and induced genes in patients with liver cancer unravels novel anticancer targets
Purpose: We utilized whole-genome mapping of promoters that are activated by DNA
hypomethylation in hepatocellular carcinoma (HCC) clinical samples to shortlist novel …
hypomethylation in hepatocellular carcinoma (HCC) clinical samples to shortlist novel …
Nutrigenomics: an inimitable interaction amid genomics, nutrition and health
Nutrigenomics is a study of how the genes and diet of a person interact. An individual's diet
regime can drive gene regulation and its downstream ultimatum towards health illness …
regime can drive gene regulation and its downstream ultimatum towards health illness …