Stilbenoids remodel the DNA methylation patterns in breast cancer cells and inhibit oncogenic NOTCH signaling through epigenetic regulation of MAML2 …
DNA hypomethylation was previously implicated in cancer progression and metastasis. The
purpose of this study was to examine whether stilbenoids, resveratrol and pterostilbene …
purpose of this study was to examine whether stilbenoids, resveratrol and pterostilbene …
DNA demethylation and invasive cancer: implications for therapeutics
D Cheishvili, L Boureau, M Szyf - British journal of …, 2015 - Wiley Online Library
One of the hallmarks of cancer is aberrant DNA methylation, which is associated with
abnormal gene expression. Both hypermethylation and silencing of tumour suppressor …
abnormal gene expression. Both hypermethylation and silencing of tumour suppressor …
Prospects for the development of epigenetic drugs for CNS conditions
M Szyf - Nature Reviews Drug Discovery, 2015 - nature.com
Advances in our understanding of the epigenetic mechanisms that control gene expression
in the central nervous system (CNS) and their role in neuropsychiatric disorders are paving …
in the central nervous system (CNS) and their role in neuropsychiatric disorders are paving …
Impact of soy isoflavones on the epigenome in cancer prevention
M Pudenz, K Roth, C Gerhauser - Nutrients, 2014 - mdpi.com
Isoflavones (IF) such as genistein are cancer preventive phytochemicals found in soy and
other legumes. Epidemiological studies point to a reduced risk for hormone‑dependent …
other legumes. Epidemiological studies point to a reduced risk for hormone‑dependent …
Meta-analysis of gene expression profiles indicates genes in spliceosome pathway are up-regulated in hepatocellular carcinoma (HCC)
W Xu, H Huang, L Yu, L Cao - Medical oncology, 2015 - Springer
Hepatocellular carcinoma (HCC) is among the commonest kind of malignant tumors, which
accounts for more than 500,000 cases of newly diagnosed cancer annually. Many …
accounts for more than 500,000 cases of newly diagnosed cancer annually. Many …
Oxidative stress and epigenetic instability in human hepatocarcinogenesis
N Nishida, M Kudo - Digestive diseases, 2013 - karger.com
Hepatocellular carcinoma (HCC) is a major cause of cancer death, and its development is
influenced by the status of inflammation and oxidative stress in the liver. Although oxidative …
influenced by the status of inflammation and oxidative stress in the liver. Although oxidative …
Methyl-CpG-binding protein MBD2 plays a key role in maintenance and spread of DNA methylation at CpG islands and shores in cancer
Cancer is characterised by DNA hypermethylation and gene silencing of CpG island-
associated promoters, including tumour-suppressor genes. The methyl-CpG-binding domain …
associated promoters, including tumour-suppressor genes. The methyl-CpG-binding domain …
[HTML][HTML] DNA methylation, microRNAs, and their crosstalk as potential biomarkers in hepatocellular carcinoma
Epigenetic alterations have been identified as a major characteristic in human cancers.
Advances in the field of epigenetics have contributed significantly in refining our knowledge …
Advances in the field of epigenetics have contributed significantly in refining our knowledge …
Aberrant expression of cell cycle and material metabolism related genes contributes to hepatocellular carcinoma occurrence
H Yan, Z Li, Q Shen, Q Wang, J Tian, Q Jiang… - Pathology-Research and …, 2017 - Elsevier
This study aims to deepen our understanding of the molecular mechanism underlying the
occurrence of hepatocellular carcinoma (HCC). We first downloaded a gene expression …
occurrence of hepatocellular carcinoma (HCC). We first downloaded a gene expression …
Identification of platform-independent diagnostic biomarker panel for hepatocellular carcinoma using large-scale transcriptomics data
The high mortality rate of hepatocellular carcinoma (HCC) is primarily due to its late
diagnosis. In the past, numerous attempts have been made to design genetic biomarkers for …
diagnosis. In the past, numerous attempts have been made to design genetic biomarkers for …