Stilbenoids remodel the DNA methylation patterns in breast cancer cells and inhibit oncogenic NOTCH signaling through epigenetic regulation of MAML2 …

K Lubecka, L Kurzava, K Flower, H Buvala… - …, 2016 - academic.oup.com
DNA hypomethylation was previously implicated in cancer progression and metastasis. The
purpose of this study was to examine whether stilbenoids, resveratrol and pterostilbene …

DNA demethylation and invasive cancer: implications for therapeutics

D Cheishvili, L Boureau, M Szyf - British journal of …, 2015 - Wiley Online Library
One of the hallmarks of cancer is aberrant DNA methylation, which is associated with
abnormal gene expression. Both hypermethylation and silencing of tumour suppressor …

Prospects for the development of epigenetic drugs for CNS conditions

M Szyf - Nature Reviews Drug Discovery, 2015 - nature.com
Advances in our understanding of the epigenetic mechanisms that control gene expression
in the central nervous system (CNS) and their role in neuropsychiatric disorders are paving …

Impact of soy isoflavones on the epigenome in cancer prevention

M Pudenz, K Roth, C Gerhauser - Nutrients, 2014 - mdpi.com
Isoflavones (IF) such as genistein are cancer preventive phytochemicals found in soy and
other legumes. Epidemiological studies point to a reduced risk for hormone‑dependent …

Meta-analysis of gene expression profiles indicates genes in spliceosome pathway are up-regulated in hepatocellular carcinoma (HCC)

W Xu, H Huang, L Yu, L Cao - Medical oncology, 2015 - Springer
Hepatocellular carcinoma (HCC) is among the commonest kind of malignant tumors, which
accounts for more than 500,000 cases of newly diagnosed cancer annually. Many …

Oxidative stress and epigenetic instability in human hepatocarcinogenesis

N Nishida, M Kudo - Digestive diseases, 2013 - karger.com
Hepatocellular carcinoma (HCC) is a major cause of cancer death, and its development is
influenced by the status of inflammation and oxidative stress in the liver. Although oxidative …

Methyl-CpG-binding protein MBD2 plays a key role in maintenance and spread of DNA methylation at CpG islands and shores in cancer

C Stirzaker, JZ Song, W Ng, Q Du, NJ Armstrong… - Oncogene, 2017 - nature.com
Cancer is characterised by DNA hypermethylation and gene silencing of CpG island-
associated promoters, including tumour-suppressor genes. The methyl-CpG-binding domain …

[HTML][HTML] DNA methylation, microRNAs, and their crosstalk as potential biomarkers in hepatocellular carcinoma

SL Anwar, U Lehmann - World journal of gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Epigenetic alterations have been identified as a major characteristic in human cancers.
Advances in the field of epigenetics have contributed significantly in refining our knowledge …

Aberrant expression of cell cycle and material metabolism related genes contributes to hepatocellular carcinoma occurrence

H Yan, Z Li, Q Shen, Q Wang, J Tian, Q Jiang… - Pathology-Research and …, 2017 - Elsevier
This study aims to deepen our understanding of the molecular mechanism underlying the
occurrence of hepatocellular carcinoma (HCC). We first downloaded a gene expression …

Identification of platform-independent diagnostic biomarker panel for hepatocellular carcinoma using large-scale transcriptomics data

H Kaur, A Dhall, R Kumar, GPS Raghava - Frontiers in genetics, 2020 - frontiersin.org
The high mortality rate of hepatocellular carcinoma (HCC) is primarily due to its late
diagnosis. In the past, numerous attempts have been made to design genetic biomarkers for …