Abstract Fumonisin B 1 (FB 1), a common mycotoxin contaminant of maize, is known to
inhibit sphingolipid biosynthesis and has been implicated in cancer promoting activity in …

Identification of reliable and accurate molecular markers remains one of the major
challenges of contemporary biomedicine. We developed a new bioinformatic technique …

Cancer initiation and progression is an accumulation of genetic and epigenetic
modifications. DNA methylation is a common epigenetic modification that regulates gene …

DNA-demethylating agents activate tumor suppressor genes that are silenced by DNA
methylation in cancer and are therefore emerging as a novel approach to cancer therapy. 5 …

S-adenosyl methionine (SAM) is a ubiquitous methyl donor that was reported to have chemo-
protective activity against liver cancer, however the molecular footprint of SAM is unknown …

Abnormal DNA methylation orchestrates many of the cancer‐related gene expression
irregularities such as the inactivation of tumour suppressor genes through hypermethylation …

Osteosarcoma (OS) is an aggressive and highly metastatic form of primary bone cancer
affecting young children and adults. Previous studies have shown that hypomethylation of …

Background Epigenetic alterations, such as aberrant DNA methylation of promoter and
enhancer regions, which lead to atypical gene expression, have been associated with …

The predisposition of patients with Hepatitis C virus (HCV) infection to hepatocellular
carcinoma (HCC) involves components of viral infection, inflammation and time. The …

The crosstalk between oncogenic signaling pathways plays a crucial role in driving cancer
development. We previously demonstrated that dietary polyphenols, specifically resveratrol …