The impact of maternal high-fat diet on offspring neurodevelopment

G Urbonaite, A Knyzeliene, FS Bunn… - Frontiers in …, 2022 - frontiersin.org
A maternal high-fat diet affects offspring neurodevelopment with long-term consequences on
their brain health and behavior. During the past three decades, obesity has rapidly …

A comprehensive approach to modeling maternal immune activation in rodents

MC Bucknor, A Gururajan, RC Dale… - Frontiers in …, 2022 - frontiersin.org
Prenatal brain development is a highly orchestrated process, making it a very vulnerable
window to perturbations. Maternal stress and subsequent inflammation during pregnancy …

[HTML][HTML] Habitual daily intake of a sweet and fatty snack modulates reward processing in humans

SE Thanarajah, AG DiFeliceantonio, K Albus… - Cell metabolism, 2023 - cell.com
Western diets rich in fat and sugar promote excess calorie intake and weight gain; however,
the underlying mechanisms are unclear. Despite a well-documented association between …

High-fat food biases hypothalamic and mesolimbic expression of consummatory drives

CM Mazzone, J Liang-Guallpa, C Li, NS Wolcott… - Nature …, 2020 - nature.com
Maintaining healthy body weight is increasingly difficult in our obesogenic environment.
Dieting efforts are often overpowered by the internal drive to consume energy-dense foods …

Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21

V Pena-Leon, C Folgueira, S Barja-Fernández… - Nature …, 2022 - nature.com
Early-life determinants are thought to be a major factor in the rapid increase of obesity.
However, while maternal nutrition has been extensively studied, the effects of breastfeeding …

Female aging: when translational models don't translate

G Gilmer, ZR Hettinger, Y Tuakli-Wosornu, E Skidmore… - Nature aging, 2023 - nature.com
For many pathologies associated with aging, female patients present with higher morbidity
and more frequent adverse events from treatments compared to male patients. While …

AgRP neurons coordinate the mitigation of activity-based anorexia

AK Sutton Hickey, SC Duane, LE Mickelsen… - Molecular …, 2023 - nature.com
Anorexia nervosa (AN) is a debilitating and deadly disease characterized by low body mass
index due to diminished food intake, and oftentimes concurrent hyperactivity. A high …

Neurodevelopmental programming of adiposity: contributions to obesity risk

AA Skowronski, RL Leibel, CA LeDuc - Endocrine Reviews, 2024 - academic.oup.com
This review analyzes the published evidence regarding maternal factors that influence the
developmental programming of long-term adiposity in humans and animals via the central …

Can breastfeeding affect the rest of our life?

PC Lisboa, RA Miranda, LL Souza, EG Moura - Neuropharmacology, 2021 - Elsevier
The breastfeeding period is one of the most important critical windows in our development,
since milk, our first food after birth, contains several compounds, such as macronutrients …

Mechanisms underlying the cognitive and behavioural effects of maternal obesity

K Hasebe, MD Kendig, MJ Morris - Nutrients, 2021 - mdpi.com
The widespread consumption of 'western'-style diets along with sedentary lifestyles has led
to a global epidemic of obesity. Epidemiological, clinical and preclinical evidence suggests …