Dietary components can induce epigenetic changes through DNA methylation, histone
modification, and regulation of microRNAs (miRNAs). Studies of diet-induced epigenetic …

The aging process is driven by multiple mechanisms that lead to changes in energy
production, oxidative stress, homeostatic dysregulation and eventually to loss of functionality …

Abstract The World Health Organization predicts that by 2050, 2.1 billion people worldwide
will be over 60 years old, a drastic increase from only 1 billion in 2019. Considering these …

Increasing evidence links changes in epigenetic systems, such as DNA methylation, histone
modification, and non-coding RNA expression, to the occurrence of cardiovascular disease …

The prevalence of metabolic-related disorders, such as non-alcoholic fatty liver disease
(NAFLD) and type 2 diabetes mellitus (DM2), has been increasing. Therefore, developing …

Physical inactivity and a poor diet increase systemic inflammation, while chronic
inflammation can be reduced through exercise and nutritional interventions. The …

This is a longitudinal single-arm clinical trial aimed to investigate whether exercise training
would modify the whole blood methylation profile in healthy women. A total of 45 subjects …

Healthy mitochondria and their epigenetic control are essential to maintaining health,
extending life expectancy, and improving cardiovascular performance. Strategies to …

Abstract Background and Aims In the CENTRAL trial context, we found diverse liver fat
dynamics in response to different dietary interventions. Epigenetic mechanisms may …

Human phenotypes (traits) are determined by the selective use of a person's unique
genotype (DNA sequence), following exposure to environmental stimuli, such as exercise …