The behaviour and ecology of the zebrafish, Danio rerio

R Spence, G Gerlach, C Lawrence… - Biological reviews, 2008 - Wiley Online Library
The zebrafish Danio rerio, is an important model organism in developmental genetics,
neurophysiology and biomedicine, but little is known about its natural ecology and …

Headwaters of the zebrafish—emergence of a new model vertebrate

DJ Grunwald, JS Eisen - Nature reviews genetics, 2002 - nature.com
The understanding of vertebrate development has advanced considerably in recent years,
primarily due to the study of a few model organisms. The zebrafish, the newest of these …

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

M Yuan, N Konstantopoulos, J Lee, L Hansen, ZW Li… - Science, 2001 - science.org
We show that high doses of salicylates reverse hyperglycemia, hyperinsulinemia, and
dyslipidemia in obese rodents by sensitizing insulin signaling. Activation or overexpression …

The state of the art of the zebrafish model for toxicology and toxicologic pathology research—advantages and current limitations

JM Spitsbergen, ML Kent - Toxicologic pathology, 2003 - journals.sagepub.com
The zebrafish (Danio rerio) is now the pre-eminent vertebrate model system for clarification
of the roles of specific genes and signaling pathways in development. The zebrafish …

[HTML][HTML] The zebrafish glypican knypek controls cell polarity during gastrulation movements of convergent extension

J Topczewski, DS Sepich, DC Myers, C Walker… - Developmental cell, 2001 - cell.com
Mutations in the zebrafish knypek locus impair gastrulation movements of convergent
extension that narrow embryonic body and elongate it from head to tail. We demonstrate that …

Life spans and senescent phenotypes in two strains of Zebrafish (Danio rerio)

GS Gerhard, EJ Kauffman, X Wang, R Stewart… - Experimental …, 2002 - Elsevier
Zebrafish have become a widely used model organism in developmental biology research.
In order to initiate an experimental foundation for aging studies, we have determined some …

[HTML][HTML] Fibronectin regulates epithelial organization during myocardial migration in zebrafish

LA Trinh, DYR Stainier - Developmental cell, 2004 - cell.com
Several genes have been implicated in heart tube formation, yet we know little about
underlying cellular mechanisms. We analyzed the cellular architecture of the migrating …

Cultured adult cardiac myocytes: future applications, culture methods, morphological and electrophysiological properties

JS Mitcheson, JC Hancox, AJ Levi - Cardiovascular research, 1998 - academic.oup.com
Isolated adult cardiac myocytes maintained in primary culture have been used as a model of
the adult myocardium for 20 years. With the recent advances and current interest in using …

[HTML][HTML] Positional cloning identifies zebrafish one-eyed pinhead as a permissive EGF-related ligand required during gastrulation

J Zhang, WS Talbot, AF Schier - Cell, 1998 - cell.com
The zebrafish one-eyed pinhead (oep) mutation disrupts embryonic development, resulting
in cyclopia and defects in endoderm, prechordal plate, and ventral neuroectoderm …

UDP-glucose dehydrogenase required for cardiac valve formation in zebrafish

EC Walsh, DYR Stainier - Science, 2001 - science.org
Cardiac valve formation is a complex process that involves cell signaling events between
the myocardial and endocardial layers of the heart across an elaborate extracellular matrix …