The telomere is a special functional complex at the end of linear eukaryotic chromosomes,
consisting of tandem repeat DNA sequences and associated proteins. It is essential for …

DNA methylation is one of the most extensively studied epigenetic marks. It is involved in
transcriptional gene silencing and plays important roles during mammalian development. Its …

Despite the importance of DNA methylation in health and disease, technologies to readily
manipulate methylation of specific sequences for functional analysis and therapeutic …

Nonalcoholic fatty liver disease (NAFLD) is a widespread hepatic disorder in the United
States and other Westernized countries. Nonalcoholic steatohepatitis (NASH), an advanced …

Epigenetic modifications help orchestrate sweeping developmental, aging, and disease-
causing changes in phenotype by altering transcriptional activity in multiple genes spanning …

OBJECTIVE: To review currently available literature on the association between imprinting
disorders (Beckwith-Wiedemann syndrome [BWS], Angelman syndrome [AS] and …

Oxidative stress and abnormal DNA methylation have been implicated in the
pathophysiology of autism. We investigated the dynamics of an integrated metabolic …

Epigenetic modifications include DNA methylation and covalent modification of histones.
These alterations are reversible but very stable and exert a significant impact on the …

Traditionally it has been widely accepted that our genes together with adult lifestyle factors
determine our risk of developing non-communicable diseases such as type 2 diabetes …

The hallmarks of carcinogenesis are aberrations in gene expression and protein function
caused by both genetic and epigenetic modifications. Epigenetics refers to the changes in …