More than a hundred genes have been identified that, when disrupted, impart large risk for
autism spectrum disorder (ASD). Current knowledge about the encoded proteins—although …

Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, shaping, motility and intracellular transport. Despite their functional heterogeneity …

Since the documented observations of Kanner in 1943, there has been great debate about
the diagnoses, the sub-types, and the diagnostic threshold that relates to what is now known …

Social deficit is a core clinical feature of autism spectrum disorder (ASD) but the underlying
neural mechanisms remain largely unclear. We demonstrate that structural and functional …

There is a growing understanding that pathological genetic variation and environmental
insults during sensitive periods in brain development have long-term consequences on …

Only relatively recently has it become clear that mammalian genomes encode tens of
thousands of long non-coding RNAs (lncRNAs). A striking 40% of these are expressed …

Recent progress in the identification of genes and genomic regions contributing to autism
spectrum disorder (ASD) has had a broad impact on our understanding of the nature of …

Human neuroimaging studies suggest that aberrant neural connectivity underlies
behavioural deficits in autism spectrum disorders (ASDs), but the molecular and neural …

Gene Ontology analyses of autism spectrum disorders (ASD) risk genes have repeatedly
highlighted synaptic function and transcriptional regulation as key points of convergence …

Autism spectrum disorders (ASD) are characterized by two seemingly unrelated symptom
domains—deficits in social interactions and restrictive, repetitive patterns of behavioral …