Advances in the profiling of DNA modifications: cytosine methylation and beyond
Chemical modifications of DNA have been recognized as key epigenetic mechanisms for
maintenance of the cellular state and memory. Such DNA modifications include canonical 5 …
maintenance of the cellular state and memory. Such DNA modifications include canonical 5 …
DNA methylation based biomarkers: practical considerations and applications
AH Kit, HM Nielsen, J Tost - Biochimie, 2012 - Elsevier
A biomarker is a molecular target analyzed in a qualitative or quantitative manner to detect
and diagnose the presence of a disease, to predict the outcome and the response to a …
and diagnose the presence of a disease, to predict the outcome and the response to a …
Birthweight is associated with DNA promoter methylation of the glucocorticoid receptor in human placenta
AC Filiberto, MA Maccani, DC Koestler… - Epigenetics, 2011 - Taylor & Francis
Birthweight has been associated with a number of health outcomes throughout life. Crucial
to proper infant growth and development is the placenta, and alterations to placental gene …
to proper infant growth and development is the placenta, and alterations to placental gene …
Targeted sequence capture as a powerful tool for evolutionary analysis1
Next‐generation sequencing technologies (NGS) have revolutionized biological research by
significantly increasing data generation while simultaneously decreasing the time to data …
significantly increasing data generation while simultaneously decreasing the time to data …
Epigenome-wide ovarian cancer analysis identifies a methylation profile differentiating clear-cell histology with epigenetic silencing of the HERG K+ channel
MS Cicek, DC Koestler, BL Fridley… - Human molecular …, 2013 - academic.oup.com
Ovarian cancer remains the leading cause of death in women with gynecologic
malignancies, despite surgical advances and the development of more effective …
malignancies, despite surgical advances and the development of more effective …
Epigenetic regulation of the glucocorticoid receptor promoter 17 in adult rats
Regulation of glucocorticoid receptor (GR) levels is an important stress adaptation
mechanism. Transcription factor Nfgi-a and environmentally induced Gr promoter 17 …
mechanism. Transcription factor Nfgi-a and environmentally induced Gr promoter 17 …
Analyzing the cancer methylome through targeted bisulfite sequencing
EJ Lee, J Luo, JM Wilson, H Shi - Cancer letters, 2013 - Elsevier
Bisulfite conversion of genomic DNA combined with next-generation sequencing (NGS) has
become a very effective approach for mapping the whole-genome and sub-genome wide …
become a very effective approach for mapping the whole-genome and sub-genome wide …
Nasal cell DNA methylation, inflammation, lung function and wheezing in children with asthma
Aims: DNA methylation is increasingly proposed as a mechanism for underlying asthma-
related inflammation. However, epigenetic studies are constrained by uncertainties on …
related inflammation. However, epigenetic studies are constrained by uncertainties on …
[HTML][HTML] Human cancer classification: a systems biology-based model integrating morphology, cancer stem cells, proteomics, and genomics
HA Idikio - Journal of Cancer, 2011 - ncbi.nlm.nih.gov
Human cancer classification is currently based on the idea of cell of origin, light and electron
microscopic attributes of the cancer. What is not yet integrated into cancer classification are …
microscopic attributes of the cancer. What is not yet integrated into cancer classification are …
Targeted bisulfite sequencing by solution hybrid selection and massively parallel sequencing
EJ Lee, L Pei, G Srivastava, T Joshi… - Nucleic acids …, 2011 - academic.oup.com
We applied a solution hybrid selection approach to the enrichment of CpG islands (CGIs)
and promoter sequences from the human genome for targeted high-throughput bisulfite …
and promoter sequences from the human genome for targeted high-throughput bisulfite …