Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Primary cilia are solitary, immotile sensory organelles present on most cells in the body that
participate broadly in human health, physiology and disease. Cilia generate a unique …

Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

INTRODUCTION Mutations in two genes, PKD1 and PKD2, are responsible for about 85 and
10% of all cases of autosomal dominant polycystic kidney disease (ADPKD), one of the most …

Mutations in the polycystin genes, PKD1 or PKD2, results in Autosomal Dominant Polycystic
Kidney Disease (ADPKD). Although a genetic basis of ADPKD is established, we lack a …

To execute their many vital functions, cell membranes are highly organized. Here, we review
how membrane structure shapes signal transduction across membranes. Recent …

Mutations in either polycystin-1 (PC1 or PKD1) or polycystin-2 (PC2, PKD2 or TRPP1) cause
autosomal-dominant polycystic kidney disease (ADPKD) through unknown mechanisms …

Polycystin subunits can form hetero-and homotetrameric ion channels in the membranes of
various compartments of the cell. Homotetrameric polycystin channels are voltage-and …

Transient receptor potential mucolipin 1 (TRPML1) is a Ca2+-releasing cation channel that
mediates the calcium signalling and homeostasis of lysosomes. Mutations in TRPML1 lead …

Transient receptor potential (TRP) ion channels are evolutionarily ancient sensory proteins
that detect and integrate a wide range of physical and chemical stimuli. TRP channels are …