Anthracyclines have been important and effective treatments against a number of cancers
since their discovery. However, their use in therapy has been complicated by severe side …

Highlights•The most common reason for the failure of the cancer treatment is the evolving
drug resistance.•The ABC transporters mainly P-gp, BCRP and MRP1 are responsible for …

Innate and acquired resistance towards the conventional therapeutic regimen imposes a
significant challenge for the successful management of cancer for decades. In patients with …

Introduction Altered epigenetic map is frequently observed in cancer and recent
investigations have demonstrated a pertinent role of epigenetic modifications in the …

Despite some advances in targeted therapeutics of human cancers, curative cancer
treatment still remains a tremendous challenge due to the occurrence of drug resistance. A …

Gastrointestinal (GI) cancer represents a major global health problem due to its aggressive
characteristics and poor prognosis. Despite the progress achieved in the development of …

At present, after extensive studies in the field of cancer, cancer stem cells (CSCs) have been
proposed as a major factor in tumor initiation, progression, metastasis, and recurrence …

The discovery of therapeutic miRNAs is one of the most exciting challenges for
pharmaceutical companies. Since the first miRNA was discovered in 1993, our knowledge of …

Simple Summary Cisplatin resistance is a common issue that affects patients with a variety
of cancers who are treated with this drug. In this research, we present a novel epigenetic …

Heparosan as the precursor for heparin biosynthesis has attracted intensive attention while
Escherichia coli Nissle 1917 (EcN) has been applied as a chassis for heparosan …